Molecular Biology Scientist

The company are a clinical stage biopharmaceutical company pioneering the discovery, development, and commercialization of allogeneic, off-the-shelf, invariant natural killer T (iNKT) cell therapies to treat cancer and other immune-mediated diseases. iNKT cells are a distinct T cell population that combine durable memory responses with the rapid cytolytic features of natural killer (NK) cells. iNKT cells offer distinct therapeutic advantages as a platform for allogeneic therapy in that the cells naturally home to tissues, aid clearance of tumors and infected cells and suppress Graft versus Host Disease (GvHD). Our proprietary platform is designed to facilitate scalable and reproducible manufacturing for off-the-shelf delivery. As such, we believe that our approach represents a highly versatile application for therapeutic development in cancer and immune diseases.

They have leveraged our platform and manufacturing capabilities to develop a wholly owned pipeline for both native and engineered iNKT cells.

Job Summary:

We are currently looking for a bright, highly motivated, science-driven lab-based scientist to join our Antibody Discovery Team for a fixed term 12-month contract. You will be responsible for candidate screening and selection as well as validation and characterization of antibody molecules.

• Perform (phage or mammalian display) screenings for our CAR and iNKT engagers platforms
• Use molecular cloning and expression assays to test new candidates
• Work effectively with members of the mammalian display, genomics, and molecular biology groups
• Ensure timely delivery of data analysis packages and accurate recording of the sample-to-data process
• Responsible for high quality of documentation, laboratory notebooks and protocols.
• Presenting and communicating plans and results internally and externally
• Maintaining an awareness of current developments in the literature to support projects
• Generating clear experimental records and protocols

• Ph.D. (or MSc followed by a minimum of 3 years industry experience)
• In-depth understanding of, and experience in in vitro display bases technology (e.g. phage, mammalian display) is desirable
• Strong hands-on skills in molecular biology techniques including PCR and cloning
• Ability to quickly learn new techniques and areas of biology
• Strong interpersonal communication and effective team working with a ‘can-do’ approach to problem solving
• Ability to plan and prioritise own work in-order to meet deadline