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Associate Director – Assay Development Leader, Drug Discovery

Website northreach Northreach Limited

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  • Date Posted - 22/02/2023
  • London
  • Associate Director – Assay Development Leader, Drug Discovery
  • Starting From 61,500 per annum
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Associate Director – Assay Development Leader, Drug Discovery

The company is a privately-owned biopharmaceutical company on the look out for an experienced Associate Director that will act as the Assay Developemt Leader in a pivotal time in the company’s journey as they drive their small molecule programmes towards the clinic!

  • Contribute to project progression by designing and implementing biochemical and cell-based screening and profiling assays and designing screening cascades to identify molecules with characteristics meeting the Therapeutic Target Profile.
  • Lead a team of assay development and screening scientists.
  • Develop, evaluate, optimise and implement novel technologies and methods for process improvement.
  • Analyse, interpret and report research findings.
  • Play a key role in the strategy and the decision-making process to select best drug molecule candidates.
  • Collate results, manage drug molecule data within the project and contribute to reports where applicable.
EXPERIENCE WE ARE LOOKING FOR (E – Essential P – Preferred)
  • Experience with 2D & 3D cell-based assays e.g., binding and blocking assays, reporter assays, signalling assays, mediator release
  • Experience with biochemical assays such as ELISA, Luminex, HTRF, Alphascreen and FRET
  • Determination of drug EC50 and IC50 and monitoring of key QC parameters
  • Prior experience with using automation for drug screening
  • Experience of multi-colour flow cytometry and isolation and identification of immune cells would be a further advantage.
  • Several years of line management experience, work well within a team, to have strong written and verbal communication skills, as well as good IT skills.
  • Confidence in troubleshooting, methodical, well organised, pay close attention to detail, and maintain accurate records.
  • PhD or MSc with experience in Biomedical sciences, Biochemistry, Biotechnology or related disciplines
  • 8+ years’ experience working in laboratory research in a contract research/biotech/pharma industry environment triaging small molecules in drug discovery.

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